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GNRHR2

Pseudogene in the species Homo sapiens

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GNRHR2
Identifiers
Aliases	GNRHR2, GnRH-II-R, gonadotropin releasing hormone receptor 2 (pseudogene)
External IDs	GeneCards: GNRHR2; OMA:GNRHR2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.1 Start 145,919,013 bp[1] End 145,925,341 bp[1]
Orthologs Species Human Mouse Entrez 114814 n/a Ensembl ENSG00000211451 n/a UniProt n a n/a RefSeq (mRNA) NM_057163 NM_206994 n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 1: 145.92 – 145.93 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Putative gonadotropin-releasing hormone II receptor is a protein that in humans is encoded by the GNRHR2 gene.^[3][4]

The receptor for gonadotropin-releasing hormone 2 (GnRH2) is encoded by the GnRH2 receptor (GnRHR2) gene. In non-hominoid primates and non-mammalian vertebrates, GnRHR2 encodes a seven-transmembrane G protein-coupled receptor. However, in humans, the N-terminus of the predicted protein contains a frameshift and premature stop codon. In humans, GnRHR2 transcription occurs but whether the gene produces a functional C-terminal multi-transmembrane protein is currently unresolved. Alternative splice variants have been reported. An untranscribed pseudogene of GnRHR2 is also on chromosome 14.^[4]

• Gonadotropin-releasing hormone receptor

• "Gonadotrophin-Releasing Hormone Receptors: GnRH2 Receptor". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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