Contents

5-HT_1F receptor

Protein-coding gene in the species Homo sapiens

HTR1F
Identifiers
Aliases	HTR1F, 5-HT-1F, 5-HT1F, 5HT6, HTR1EL, MR77, 5-HT1F receptor, 5-hydroxytryptamine receptor 1F
External IDs	OMIM: 182134; MGI: 99842; HomoloGene: 37361; GeneCards: HTR1F; OMA:HTR1F - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p11.2-p11.1 Start 87,792,706 bp[1] End 87,993,839 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 C1.3|16 37.1 cM Start 64,745,092 bp[2] End 64,926,217 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle islet of Langerhans Achilles tendon gonad prefrontal cortex smooth muscle tissue subcutaneous adipose tissue primary visual cortex cervix mononuclear cell Top expressed in lumbar spinal ganglion paraventricular nucleus of thalamus ventral nucleus of lateral geniculate body subthalamus ventral nuclear group multiform layer of neocortex lateral preoptic nucleus ventral lateral nucleus internal pyramidal layer of neocortex thalamic reticular nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity serotonin binding G protein-coupled serotonin receptor activity neurotransmitter receptor activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane dendrite Biological process G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway signal transduction chemical synaptic transmission G protein-coupled serotonin receptor signaling pathway G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3355 15557 Ensembl ENSG00000179097 ENSMUSG00000050783 UniProt P30939 Q02284 RefSeq (mRNA) NM_000866 NM_001322208 NM_001322209 NM_001322210 NM_008310 RefSeq (protein) NP_000857 NP_001309137 NP_001309138 NP_001309139 NP_032336 Location (UCSC) Chr 3: 87.79 – 87.99 Mb Chr 16: 64.75 – 64.93 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

5-hydroxytryptamine (serotonin) receptor 1F, also known as HTR1F is a 5-HT₁ receptor protein and also denotes the human gene encoding it.^{[5][6][7][8][9]}

Agonists[edit]

• 5-n-Butyryloxy-DMT:^[10] >60-fold selectivity versus 5-HT_1E receptor
• BRL-54443 - mixed 5-HT_1E/1F agonist
• Eletriptan - mixed 5-HT_{1B/1D/1E/1F/2B/7} agonist
• LY-334,370^[11] - as well as related benzamides^[12]
• LY-344,864 (N-[(3R)-3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluorobenzamide)
• Naratriptan - mixed 5-HT_1B/1D/1F agonist
• Lasmiditan - selective 5-HT_1F agonist, a first-in-class ditan molecule

Antagonists[edit]

MLS000756415^[13]

See also[edit]

• 5-HT₁ receptor
• 5-HT receptor

References[edit]

Further reading[edit]

External links[edit]

• "5-HT_1F". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
• Human HTR1F genome location and HTR1F gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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