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P a g e s f o r l o g g e d o u t e d i t o r s l e a r n m o r e ● C o n t r i b u t i o n s ● T a l k
( T o p )
1 S u b f a m i l y B 1
2 S u b f a m i l y B 2
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● D o w n l o a d a s P D F ● P r i n t a b l e v e r s i o n
A p p e a r a n c e
F r o m W i k i p e d i a , t h e f r e e e n c y c l o p e d i a
( R e d i r e c t e d f r o m C l a s s B G P C R )
Secretin receptor family (class B GPCR subfamily [1] secretin receptors regulated by peptide hormones from the glucagon hormone family . The family is different from adhesion G protein-coupled receptors .[2]
The secretin-receptor family of GPCRs include vasoactive intestinal peptide receptors and receptors for secretin , calcitonin and parathyroid hormone /parathyroid hormone-related peptides. These receptors activate adenylyl cyclase and the phosphatidyl-inositol-calcium pathway . The receptors in this family have 7 transmembrane helices ,[3] [4] 7TM signature.[5]
The secretin-receptor family GPCRs exist in many animal species. Data mining with the Pfam signature has identified members in fungi, although due to their presumed non-hormonal function they are more commonly referred to as Adhesion G protein-coupled receptors , making the Adhesion subfamily the more basal group.[6]
Subfamily B1 [ edit ]
Subfamily B1 contains classical hormone receptors , such as receptors for secretin and glucagon , that are all involved in cAMP-mediated signalling pathways.
Subfamily B2 [ edit ]
Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97 ; calcium-independent receptors for latrotoxin [7] brain-specific angiogenesis inhibitor receptors[8] Adhesion G protein-coupled receptors .
Subfamily B3 [ edit ]
Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.
Unclassified members [ edit ]
HCTR-5 ; HCTR-6 ; KPG 006 ; KPG 008
References [ edit ]
^ PDB : 4L6R Siu FY, He M, de Graaf C, Han GW, Yang D, Zhang Z, et al. (July 2013). "Structure of the human glucagon class B G-protein-coupled receptor" . Nature . 499 (7459): 444–9. Bibcode :2013Natur.499..444S . doi :10.1038/nature12393 . PMC 3820480 PMID 23863937 .
^ PDB : 5VEX Song G, Yang D, Wang Y, de Graaf C, Zhou Q, Jiang S, et al. (June 2017). "Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators". Nature . 546 (7657): 312–315. Bibcode :2017Natur.546..312S . doi :10.1038/nature22378 . PMID 28514449 . S2CID 2141649 .
^ Hollenstein K, de Graaf C, Bortolato A, Wang MW, Marshall FH, Stevens RC (January 2014). "Insights into the structure of class B GPCRs" . Trends in Pharmacological Sciences . 35 1 ): 12–22. doi :10.1016/j.tips.2013.11.001 . PMC 3931419 PMID 24359917 .
^ Krishnan A, Almén MS, Fredriksson R, Schiöth HB (2012). Xue C (ed.). "The origin of GPCRs: identification of mammalian like Rhodopsin, Adhesion, Glutamate and Frizzled GPCRs in fungi" . PLOS ONE . 7 1 ): e29817. Bibcode :2012PLoSO...729817K . doi :10.1371/journal.pone.0029817 PMC 3251606 PMID 22238661 .
^ Universal protein resource accession number O94910 at UniProt .
^ Universal protein resource accession number O14514 at UniProt .
R e t r i e v e d f r o m " https://en.wikipedia.org/w/index.php?title=Secretin_receptor_family&oldid=1190618482 " C a t e g o r i e s : ● P r o t e i n d o m a i n s ● P r o t e i n f a m i l i e s ● G p r o t e i n - c o u p l e d r e c e p t o r s H i d d e n c a t e g o r i e s : ● A r t i c l e s w i t h s h o r t d e s c r i p t i o n ● S h o r t d e s c r i p t i o n i s d i f f e r e n t f r o m W i k i d a t a ● P r o t e i n p a g e s n e e d i n g a p i c t u r e
● T h i s p a g e w a s l a s t e d i t e d o n 1 8 D e c e m b e r 2 0 2 3 , a t 2 2 : 5 4 ( U T C ) . ● T e x t i s a v a i l a b l e u n d e r t h e C r e a t i v e C o m m o n s A t t r i b u t i o n - S h a r e A l i k e L i c e n s e 4 . 0 ;
a d d i t i o n a l t e r m s m a y a p p l y . B y u s i n g t h i s s i t e , y o u a g r e e t o t h e T e r m s o f U s e a n d P r i v a c y P o l i c y . W i k i p e d i a ® i s a r e g i s t e r e d t r a d e m a r k o f t h e W i k i m e d i a F o u n d a t i o n , I n c . , a n o n - p r o f i t o r g a n i z a t i o n . ● P r i v a c y p o l i c y ● A b o u t W i k i p e d i a ● D i s c l a i m e r s ● C o n t a c t W i k i p e d i a ● C o d e o f C o n d u c t ● D e v e l o p e r s ● S t a t i s t i c s ● C o o k i e s t a t e m e n t ● M o b i l e v i e w
