|
m link mitochondrial DNA using Find link
|
m Alter: title. Add: hdl, issue, pmid. | You can use this bot yourself. Report bugs here.| Activated by User:Nemo bis | via #UCB_webform
|
||
| Line 3: | Line 3: | ||
== Function == |
== Function == |
||
Mitochondria contain around 1000 proteins in [[yeast]] and 1500 proteins in humans; however only 8 and 13 proteins are encoded in [[mitochondrial DNA]] in yeast and human, respectively. Most mitochondrial proteins are synthesized via cytoplasmic ribosomes.<ref name="WenzOpaliński2015">{{cite journal|last1=Wenz|first1=Lena-Sophie|last2=Opaliński|first2=Łukasz|last3=Wiedemann|first3=Nils|last4=Becker|first4=Thomas|title=Cooperation of protein machineries in mitochondrial protein sorting|journal=Biochimica et Biophysica Acta (BBA) - Molecular Cell Research|volume=1853|issue=5|year=2015|pages=1119–1129|issn=0167-4889|doi=10.1016/j.bbamcr.2015.01.012}}</ref> Proteins that are the key components in the [[electron transport chain]] are translated in mitochondria.<ref name="JohnstonWilliams2016">{{cite journal|last1=Johnston|first1=Iain G.|last2=Williams|first2=Ben P.|title=Evolutionary Inference across Eukaryotes Identifies Specific Pressures Favoring Mitochondrial Gene Retention|journal=Cell Systems|year=2016|issn=2405-4712|doi=10.1016/j.cels.2016.01.013|volume=2|pages=101–111|pmid=27135164}}</ref><ref name="Hamers2016">{{cite journal|last1=Hamers|first1=Laurel|title=Why do our |
Mitochondria contain around 1000 proteins in [[yeast]] and 1500 proteins in humans; however only 8 and 13 proteins are encoded in [[mitochondrial DNA]] in yeast and human, respectively. Most mitochondrial proteins are synthesized via cytoplasmic ribosomes.<ref name="WenzOpaliński2015">{{cite journal|last1=Wenz|first1=Lena-Sophie|last2=Opaliński|first2=Łukasz|last3=Wiedemann|first3=Nils|last4=Becker|first4=Thomas|title=Cooperation of protein machineries in mitochondrial protein sorting|journal=Biochimica et Biophysica Acta (BBA) - Molecular Cell Research|volume=1853|issue=5|year=2015|pages=1119–1129|issn=0167-4889|doi=10.1016/j.bbamcr.2015.01.012|pmid=25633533}}</ref> Proteins that are the key components in the [[electron transport chain]] are translated in mitochondria.<ref name="JohnstonWilliams2016">{{cite journal|last1=Johnston|first1=Iain G.|last2=Williams|first2=Ben P.|title=Evolutionary Inference across Eukaryotes Identifies Specific Pressures Favoring Mitochondrial Gene Retention|journal=Cell Systems|year=2016|issn=2405-4712|doi=10.1016/j.cels.2016.01.013|volume=2|issue=2|pages=101–111|pmid=27135164}}</ref><ref name="Hamers2016">{{cite journal|last1=Hamers|first1=Laurel|title=Why do our cell's power plants have their own DNA?|journal=Science|year=2016|issn=0036-8075|doi=10.1126/science.aaf4083}}</ref> |
||
== Structure == |
== Structure == |
||
[[Mammals|Mammalian]] mitoribosomes have small 28S and large 39S subunits, together forming a 55S mitoribosome.<ref name="GreberBieri2015">{{Cite journal |author1=Basil J. Greber |author2=Philipp Bieri |author3=Marc Leibundgut |author4=Alexander Leitner |author5=Ruedi Aebersold |author6=Daniel Boehringer |author7=Nenad Ban |title = Ribosome. The complete structure of the 55S mammalian mitochondrial ribosome |journal = [[Science (journal)|Science]] |volume = 348 |issue = 6232 |pages = 303–308 |year = 2015 |doi = 10.1126/science.aaa3872 |pmid = 25837512 }}</ref> |
[[Mammals|Mammalian]] mitoribosomes have small 28S and large 39S subunits, together forming a 55S mitoribosome.<ref name="GreberBieri2015">{{Cite journal |author1=Basil J. Greber |author2=Philipp Bieri |author3=Marc Leibundgut |author4=Alexander Leitner |author5=Ruedi Aebersold |author6=Daniel Boehringer |author7=Nenad Ban |title = Ribosome. The complete structure of the 55S mammalian mitochondrial ribosome |journal = [[Science (journal)|Science]] |volume = 348 |issue = 6232 |pages = 303–308 |year = 2015 |doi = 10.1126/science.aaa3872 |pmid = 25837512 |hdl=20.500.11850/100390 }}</ref> |
||
== Genes == |
== Genes == |
||
Mitochondrial ribosomeormitoribosome is a protein complex that is active in mitochondria and functions as a riboprotein for translating mitochondrial mRNAs encoded in mtDNA. Mitoribosomes, like cytoplasmic ribosomes, consist of two subunits — large (mtLSU) and small (mt-SSU).[1] However, the ratio of rRNA/protein is different from cytoplasmic ribosomes, mitoribosomes consist of several specific proteins and less rRNAs.[1]
Mitochondria contain around 1000 proteins in yeast and 1500 proteins in humans; however only 8 and 13 proteins are encoded in mitochondrial DNA in yeast and human, respectively. Most mitochondrial proteins are synthesized via cytoplasmic ribosomes.[2] Proteins that are the key components in the electron transport chain are translated in mitochondria.[3][4]
Mammalian mitoribosomes have small 28S and large 39S subunits, together forming a 55S mitoribosome.[5]
|
| |||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Proteins |
| ||||||||||||||||||||||||||||||||
| Other concepts |
| ||||||||||||||||||||||||||||||||
|
Ribosomal RNA / ribosome subunits
| |||||||
|---|---|---|---|---|---|---|---|
| Archaea (70S) |
Small (30S): | ||||||
| Bacteria (70S) |
Small (30S): | ||||||
| Eukaryotes |
| ||||||
| Ribosomal proteins | (See article table) | ||||||
 | This molecularorcell biology article is a stub. You can help Wikipedia by expanding it. |
