Activating transcription factor 6, also known as ATF6, is a protein that, in humans, is encoded by the ATF6 gene[5][6][7] and is involved in the unfolded protein response.
ATF6 is an endoplasmic reticulum (ER) stress-regulated transmembrane transcription factor that activates the transcription of ER molecules.[8] Accumulation of misfolded proteins in the Endoplasmic Reticulum results in the proteolytic cleavage of ATF6. The cytosolic portion of ATF6 will move to the nucleus and act as a transcription factor to cause the transcription of ER chaperones.
ATF6 has been shown to interact with YY1[9] and Serum response factor.[6]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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