Contents

HOXC6

Protein-coding gene in the species Homo sapiens

HOXC6
Identifiers
Aliases	HOXC6, CP25, HHO.C8, HOX3, HOX3C, homeobox C6
External IDs	OMIM: 142972; MGI: 96197; HomoloGene: 19533; GeneCards: HOXC6; OMA:HOXC6 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.13 Start 53,990,624 bp[1] End 54,030,823 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 F3|15 58.06 cM Start 102,906,689 bp[2] End 102,920,313 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in renal medulla caput epididymis germinal epithelium nipple saphenous vein corpus epididymis skin of hip Skeletal muscle tissue of rectus abdominis spinal ganglia lactiferous duct Top expressed in tail of embryo thoracic vertebral column efferent ductule muscle of thigh genital tubercle female urethra adrenal gland male urethra lumbar subsegment of spinal cord yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity sequence-specific DNA binding DNA binding transcription corepressor activity DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Cellular component nucleus nucleoplasm cytosol Biological process regulation of transcription by RNA polymerase II regulation of transcription, DNA-templated transcription, DNA-templated anterior/posterior pattern specification embryonic skeletal system development negative regulation of nucleic acid-templated transcription multicellular organism development positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3223 15425 Ensembl ENSG00000197757 ENSMUSG00000001661 UniProt P09630 P10629 RefSeq (mRNA) NM_153693 NM_004503 NM_010465 RefSeq (protein) NP_004494 NP_710160 NP_034595 Location (UCSC) Chr 12: 53.99 – 54.03 Mb Chr 15: 102.91 – 102.92 Mb PubMed search [3] [4]
Wikidata
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Homeobox protein Hox-C6 is a protein that in humans is encoded by the HOXC6 gene.^[5][6][7] Hox-C6 expression is highest in the fallopian tube and ovary.^[8] HoxC6 has been highly expressed in many types of cancers including prostate, breast, and esophageal squamous cell cancer.^[9]

This gene belongs to the homeobox family, members of which encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC6, is one of several HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Alternatively spliced transcript variants encoding different isoforms have been identified for HOXC6. Transcript variant two includes the shared exon, and transcript variant one includes only gene-specific exons.^[7] HOXC6 plays a role in lymphoma. The HOXC6 isoform, HOXC6-2 is an active carcinogenic  for gastric cancer. It stimulates gastric cancer cells proliferation by acting as an oncogene. Downregulation of this gene’s isoforms could potentially lead to less proliferation of certain cancerous cells. With the HOXC6-1 isoform, there were no statistically significant effects on migration, invasion, apoptosis, or proliferation when it was downregulated.^[10] According to a study in Cancer Cell International, suppression of the HOXC6 gene plays a role in blocking the TGF-β/SMAD cascade. This then leads to the weakening of epithelial to mesenchymal transition for the cervical carcinoma.^[11]

A knockout model using small interfering RNA showed that knockout of HOXC6 was associated with apoptosis. Additionally, the presence of HOXC6 was associated with inhibition of paclitaxel-induced apoptosis. Thus, HOXC6 was demonstrated to induce proliferative activity.^[12]

• Homeobox

• HOXC6+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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