Contents

DIDO1

Protein-coding gene in the species Homo sapiens

DIDO1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2M3H, 4L7X
Identifiers
Aliases	DIDO1, BYE1, C20orf158, DATF-1, DATF1, DIDO2, DIDO3, DIO-1, DIO1, dJ885L7.8, death inducer-obliterator 1
External IDs	OMIM: 604140; MGI: 1344352; HomoloGene: 34139; GeneCards: DIDO1; OMA:DIDO1 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.33 Start 62,877,738 bp[1] End 62,937,952 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H4 Start 180,299,757 bp[2] End 180,351,792 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell sural nerve right uterine tube tendon of biceps brachii body of uterus Achilles tendon olfactory zone of nasal mucosa left ovary popliteal artery tibial arteries Top expressed in Paneth cell Rostral migratory stream atrioventricular valve maxillary prominence mandibular prominence ciliary body epithelium of lens medullary collecting duct primitive streak retinal pigment epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding RNA binding Cellular component cytoplasm spindle cytoskeleton nucleus Biological process apoptotic signaling pathway transcription, DNA-templated apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11083 23856 Ensembl ENSG00000101191 ENSMUSG00000038914 UniProt Q9BTC0 Q8C9B9 RefSeq (mRNA) NM_001193369 NM_001193370 NM_022105 NM_033081 NM_080796 NM_080797 NM_152302 NM_001291432 NM_001291433 NM_011805 NM_175551 NM_177852 RefSeq (protein) NP_001180298 NP_001180299 NP_071388 NP_149072 NP_542986 NP_542987 NP_001278361 NP_001278362 NP_035935 NP_780760 NP_808520 Location (UCSC) Chr 20: 62.88 – 62.94 Mb Chr 2: 180.3 – 180.35 Mb PubMed search [3] [4]
Wikidata
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Death-inducer obliterator 1 is a protein that in humans is encoded by the DIDO1 gene.^[5][6]

Function[edit]

Apoptosis, a major form of cell death, is an efficient mechanism for eliminating unwanted cells and is of central importance for development and homeostasis in metazoan animals. In mice, the death inducer-obliterator-1 gene is upregulated by apoptotic signals and encodes a cytoplasmic protein that translocates to the nucleus upon apoptotic signal activation. When overexpressed, the mouse protein induced apoptosis in cell lines growing in vitro. This gene is similar to the mouse gene and therefore is thought to be involved in apoptosis. Alternatively spliced transcripts have been found for this gene, encoding multiple isoforms.^[6]

References[edit]

Further reading[edit]

External links[edit]

• DIDO1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by expanding it.