Y box binding protein 1 also known as Y-box transcription factorornuclease-sensitive element-binding protein 1 is a protein that in humans is encoded by the YBX1 gene.[5] YBX1 is an RNA binding protein[6] that stabilises messenger RNAs modified with N6-methyladenosine.[7]
YBX1 is a potential drug target in cancer therapy.[8] YB-1 helps the replication of adenovirus type 5, a commonly used vector in gene therapy.[8] Thus, YB-1 can cause an "oncolytic" effect in YB-1 positive cancer cells treated with adenoviruses.
Y box binding protein 1 has been shown to interact with:
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1h95: SOLUTION STRUCTURE OF THE SINGLE-STRANDED DNA-BINDING COLD SHOCK DOMAIN (CSD) OF HUMAN Y-BOX PROTEIN 1 (YB1) DETERMINED BY NMR (10 LOWEST ENERGY STRUCTURES)
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.