Contents

HOXB5

Protein-coding gene in humans

HOXB5
Identifiers
Aliases	HOXB5, HHO.C10, HOX2, HOX2A, HU-1, Hox2.1, homeobox B5
External IDs	OMIM: 142960; MGI: 96186; HomoloGene: 37585; GeneCards: HOXB5; OMA:HOXB5 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.32 Start 48,591,257 bp[1] End 48,593,779 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 59.82 cM Start 96,194,162 bp[2] End 96,196,947 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon mucosa of ileum corpus epididymis pancreatic ductal cell dorsal motor nucleus of vagus nerve human kidney endometrium seminal vesicula muscle layer of sigmoid colon inferior olivary nucleus Top expressed in inferior ganglion of vagus nerve motor neuron anterior horn of spinal cord migratory enteric neural crest cell thoracic vertebral column pontine nuclei tail of embryo medullary collecting duct Paneth cell lumbar subsegment of spinal cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding DNA-binding transcription activator activity, RNA polymerase II-specific sequence-specific DNA binding DNA-binding transcription factor activity RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Cellular component fibrillar center nucleus cytosol Biological process positive regulation of transcription by RNA polymerase II anatomical structure morphogenesis transcription by RNA polymerase II regulation of transcription, DNA-templated multicellular organism development embryonic skeletal system development endothelial cell differentiation anterior/posterior pattern specification embryonic skeletal system morphogenesis transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3215 15413 Ensembl ENSG00000120075 ENSMUSG00000038700 UniProt P09067 P09079 RefSeq (mRNA) NM_002147 NM_008268 RefSeq (protein) NP_002138 NP_032294 Location (UCSC) Chr 17: 48.59 – 48.59 Mb Chr 11: 96.19 – 96.2 Mb PubMed search [3] [4]
Wikidata
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Homeobox protein Hox-B5 is a protein that in humans is encoded by the HOXB5 gene.^[5][6][7]

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue.^[7]

• Homeobox

• HOXB5+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Overview of all the structural information available in the PDB for UniProt: P02833 (Drosophila melanogaster Homeotic protein antennapedia) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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