Gamma-interferon-inducible protein Ifi-16 (Ifi-16) also known as interferon-inducible myeloid differentiation transcriptional activator is a protein that in humans is encoded by the IFI16 gene.[5][6][7]
This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53,[8] retinoblastoma-1 and BRCA1.[9] It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway.[7] IFI16 has been shown to play a role in the sensing of intracellular DNA[10] - a hallmark of virally infected cells - and has also been linked to the death of HIV-infected helper CD4 T cellsbypyroptosis, a highly inflammatory form of programmed cell death.[11][12] Recently, it has been shown how IFI16, once extracellularly released, can induce inflammation upon TLR4 binding, acting as a DAMP.[13]
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PDB gallery
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2oq0: Crystal Structure of the First HIN-200 Domain of Interferon-Inducible Protein 16
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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