Myb-related protein B is a protein that in humans is encoded by the MYBL2 gene.[5]
The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Transcript variants may exist for this gene, but their full-length natures have not been determined.[6] MYBL2 is deregulated in various cancer types and can contribute to cancer progression.[7][8]
MYBL2 has been shown to interact with:
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
PDB gallery
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1a5j: CHICKEN B-MYB DNA BINDING DOMAIN, REPEAT 2 AND REPEAT3, NMR, 32 STRUCTURES
2d9a: Solution Structure of RSGI RUH-050, a myb DNA-binding domain in mouse cDNA
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