Lysine-specific demethylase 5C is an enzyme that in humans is encoded by the KDM5C gene.[5][6][7] KDM5C belongs to the alpha-ketoglutarate-dependent hydroxylase superfamily.
This gene is a member of the SMCY homolog family and encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. The DNA-binding motif suggest this protein is involved in the regulation of transcription and chromatin remodeling. Mutations in this gene have been associated with X-linked intellectual disability. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.[7]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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1.14.11: 2-oxoglutarate |
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1.14.13: NADHorNADPH |
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1.14.14: reduced flavinorflavoprotein |
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1.14.15: reduced iron–sulfur protein |
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1.14.16: reduced pteridine (BH4 dependent) |
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1.14.17: reduced ascorbate |
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1.14.18-19: other |
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1.14.99 - miscellaneous |
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Activity |
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Regulation |
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Classification |
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Kinetics |
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Types |
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