ETS domain-containing protein Elk-4 is a protein that in humans is encoded by the ELK4 gene.[5][6][7]
This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene.[7]
ELK4 has been shown to interact with:
PDB gallery
| |
---|---|
1bc7: SERUM RESPONSE FACTOR ACCESSORY PROTEIN 1A (SAP-1)/DNA COMPLEX
1bc8: STRUCTURES OF SAP-1 BOUND TO DNA SEQUENCES FROM THE E74 AND C-FOS PROMOTERS PROVIDE INSIGHTS INTO HOW ETS PROTEINS DISCRIMINATE BETWEEN RELATED DNA TARGETS
1hbx: TERNARY COMPLEX OF SAP-1 AND SRF WITH SPECIFIC SRE DNA
1k6o: Crystal Structure of a Ternary SAP-1/SRF/c-fos SRE DNA Complex
|
| |||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| |||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
![]() | This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it. |