Krüppel-like factor 14, also known as basic transcription element-binding protein 5 (BTEB5) is a protein that in humans is encoded by the KLF14 gene.[5] The corresponding Klf14 mouse gene is known as Sp6.[6]
KLF14 is a member of the Krüppel-like factor family of transcription factors. It regulates the transcription of various genes, including TGFβRII (the type II receptor for TGFβ).[7] KLF14 is expressed in many tissues,[8] lacks introns, and is subject to parent-specific expression.[9]
KLF14 appears to be a master regulator of gene expression in adipose tissue.[10]
Like the other members of the KLF family, KLF14 has three zinc-finger domains near the C-terminus, all three of which are of the classical C2H2 type. In the human, they are at amino acids 195–219, 225–249, and 255–277.[11]
Human KLF14 is 323 amino acids in length, with a molecular weight of 33,124;[11] in the mouse its length is 325.[12]
There appears to be a connection between KLF14 and coronary artery disease, hypercholesterolemia and type 2 diabetes.[13][14]
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