Contents

ZNF638

Protein-coding gene in the species Homo sapiens

ZNF638
Identifiers
Aliases	ZNF638, NP220, ZFML, Zfp638, zinc finger protein 638
External IDs	OMIM: 614349; MGI: 1203484; HomoloGene: 7447; GeneCards: ZNF638; OMA:ZNF638 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p13.2 Start 71,276,561 bp[1] End 71,435,069 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 C3 Start 83,844,091 bp[2] End 83,966,532 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon corpus callosum cerebellar hemisphere right hemisphere of cerebellum anterior pituitary ventricular zone right uterine tube tibial nerve epithelium of colon sural nerve Top expressed in genital tubercle tail of embryo ventricular zone spermatocyte ganglionic eminence zygote granulocyte pineal gland neural layer of retina cerebellar cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding DNA binding zinc ion binding double-stranded DNA binding nucleic acid binding RNA binding Cellular component cytoplasm nuclear speck intracellular membrane-bounded organelle nucleus nucleoplasm Biological process regulation of transcription, DNA-templated transcription, DNA-templated RNA splicing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27332 18139 Ensembl ENSG00000075292 ENSMUSG00000030016 UniProt Q14966 Q61464 RefSeq (mRNA) NM_001014972 NM_001252612 NM_001252613 NM_014497 NM_001166371 NM_008717 NM_001355284 NM_001355285 NM_001355286 RefSeq (protein) NP_001014972 NP_001239541 NP_001239542 NP_055312 NP_001159843 NP_032743 NP_001342213 NP_001342214 NP_001342215 NP_001393000 NP_001393001 NP_001393002 NP_001393003 NP_001393004 NP_001393005 NP_001393006 NP_001393007 NP_001393008 NP_001393009 NP_001393010 NP_001393011 NP_001393012 NP_001393013 Location (UCSC) Chr 2: 71.28 – 71.44 Mb Chr 6: 83.84 – 83.97 Mb PubMed search [3] [4]
Wikidata
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Zinc finger protein 638 is a protein that in humans is encoded by the ZNF638 gene.^[5][6]

The protein encoded by this gene is a nucleoplasmic protein. It binds cytidine-rich sequences in double-stranded DNA. This protein has three types of domains: MH1, MH2 (repeated three times) and MH3. It is associated with packaging, transferring, or processing transcripts. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.^[6]

ZNF638 has been shown to interact with FHL2.^[7]

• ZNF638+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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