| Rel homology domain (RHD) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| |||||||||||
| Identifiers | |||||||||||
| Symbol | RHD | ||||||||||
| Pfam | PF00554 | ||||||||||
| InterPro | IPR011539 | ||||||||||
| PROSITE | PDOC00924 | ||||||||||
| SCOP2 | 1svc / SCOPe / SUPFAM | ||||||||||
| CDD | cd07827 | ||||||||||
| |||||||||||
The Rel homology domain (RHD) is a protein domain found in a family of eukaryotic transcription factors,[2] including both NF-κB and NFAT, among others. Some of these transcription factors appear to form multi-protein DNA-bound complexes.[3] Phosphorylation of the RHD appears to play a role in the regulation of some of these transcription factors, acting to modulate the expression of their target genes.[4]
The RHD is composed of two immunoglobulin-like beta barrel subdomains that grip the DNA in the major groove. The N-terminal specificity domain resembles the core domain of the p53 transcription factor, and contains a recognition loop that interacts with DNA bases. In the case of NF-κB, the C-terminal dimerization subdomain determines dimerization propensity with other proteins in the NF-κB/Rel protein family. The dimerization subdomain is immediately followed by a nuclear localization sequence that also comprises the site for inhibitory interactions with IκB.[1]
|
| |||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| |||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||
 | This protein-related article is a stub. You can help Wikipedia by expanding it. |
