Contents

Periciazine

Typical antipsychotic medication

Periciazine

Clinical data
Pregnancy category	AU:C
Routes of administration	Oral
Drug class	Typical antipsychotic
ATC code	N05AC01 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) BR: Class C1 (Other controlled substances)[1] CA: ℞-only UK: POM (Prescription only) In general: ℞ (Prescription only)
Pharmacokinetic data
Metabolism	Hepatic (mostly via conjugation)[2]
Elimination half-life	12 h[2]
Excretion	Renal[2]
Identifiers
IUPAC name 10-[3-(4-hydroxypiperidin-1-yl)propyl]-10H-phenothiazine-2-carbonitrile
CAS Number	2622-26-6 Y
PubChem CID	4747
DrugBank	DB01608 N
ChemSpider	4585 N
UNII	3405M6FD73
KEGG	D01485 Y
ChEBI	CHEBI:31981 N
ChEMBL	ChEMBL251940 N
CompTox Dashboard (EPA)	DTXSID5045910
ECHA InfoCard	100.018.248
Chemical and physical data
Formula	C21H23N3OS
Molar mass	365.50 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1CN(CCC1O)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C#N
InChI InChI=1S/C21H23N3OS/c22-15-16-6-7-21-19(14-16)24(18-4-1-2-5-20(18)26-21)11-3-10-23-12-8-17(25)9-13-23/h1-2,4-7,14,17,25H,3,8-13H2 N Key:LUALIOATIOESLM-UHFFFAOYSA-N N
NY (what is this?)  (verify)

Periciazine (INN), also known as pericyazine (BAN) or propericiazine, is a drug that belongs to the phenothiazine class of typical antipsychotics.

Periciazine is not approved for sale in the United States. It is commonly sold in Canada, Italy and Russia under the tradename Neuleptil and in United Kingdom and Australia under the tradename Neulactil.^[3]

Medical uses[edit]

The primary uses of periciazine include in the short-term treatment of severe anxiety or tension and in the maintenance treatment of psychotic disorders such as schizophrenia. There is insufficient evidence to determine whether periciazine is more or less effective than other antipsychotics.^[2] A 2014 systematic review compared periciazine with typical antipsychotics for schizophrenia:

Periciazine has also been studied in the treatment of opioid dependence.^[5]

Adverse effects[edit]

Periciazine is a rather sedating and anticholinergic antipsychotic, and despite being classed with the typical antipsychotics, its risk of extrapyramidal side effects is comparatively low.^[6] It has a relatively high risk of causing hyperprolactinaemia and a moderate risk of causing weight gain and orthostatic hypotension.^[6]

Synthesis[edit]

The final step in the synthesis involves the alkylation of 3-(2-cyanophenothiazin-10-yl)propyl 4-methylbenzenesulfonate, CID:134990672 (1) with 4-Piperidinol [5382-16-1] (2) giving Periciazine (3).

References[edit]

External links[edit]

• Neulactil - Summary of Product Characteristics from the electronic Medicines Compendium
• [1] from the Therapeutic Goods Administration.
• [2] from Health Canada.